CAS NO: | 1427782-89-5 |
包装 | 价格(元) |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | IWP L6 (Porcn Inhibitor III) is aPorcninhibitor with anEC50of 0.5 nM. | ||||||||||||||||
IC50& Target | EC50 Value: 0.5 nM[1] | ||||||||||||||||
体外研究 (In Vitro) | IWP-L6 (Porcn Inhibitor III) effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses. IWP-L6 inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys[1]. | ||||||||||||||||
体内研究 (In Vivo) | IWP-L6 (Porcn Inhibitor III) is stable in human plasma over 24 h, it was rapidly metabolized in rat plasma (t1/2 = 190 min), murine plasma (t1/2 = 2 min), and the murine liver S9 fractions (t1/2 = 26 min). The major metabolites are the amide cleavage products. Similar species-dependent metabolitic profiles due to the involvement of carboxylesterase (CES) have been reported with other drug candidates. Despite its modest metabolic stability in mouse-derived plasma, IWP-L6 was highly active in zebrafish. IWP-L6 exhibited more potent activity[1]. | ||||||||||||||||
分子量 | 472.58 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H20N4O2S2 | ||||||||||||||||
CAS 号 | 1427782-89-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 1.43 mg/mL(3.03 mM;Need ultrasonic) 配制储备液
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