CAS NO: | 2036044-77-4 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Porcn-IN-1 is potentporcupineinhibitor with anIC50of 0.5±0.2 nM. | ||||||||||||||||
IC50& Target | IC50: 0.5±0.2 nM (Porcupine inhibitor)[1] | ||||||||||||||||
体外研究 (In Vitro) | Porcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Porcupine-IN-1 is as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Porcn-IN-1 potently inhibits the secretion of Wnt3A, therefore is confirmed to be a porcupine inhibitor[1]. | ||||||||||||||||
体内研究 (In Vivo) | Porcn-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg)[1]. | ||||||||||||||||
分子量 | 410.44 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H19FN4O | ||||||||||||||||
CAS 号 | 2036044-77-4 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 100 mg/mL(243.64 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |