NLS-StAx-h TFA

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NLS-StAx-h TFA

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100 μg	电议
500 μg	电议
1mg	电议
5mg	电议
10mg	电议

产品介绍

NLS-StAx-h TFA 是选择性的、细胞可渗透的Wnt信号传导的固定肽抑制剂，IC₅₀为 1.4 μM。NLS-StAx-h TFA 可有效抑制 β-catenin-转录因子的相互作用，具有对癌细胞的抗增殖活性。

生物活性

NLS-StAx-h TFA is a selective, cell permeable, stapled peptideWntsignaling inhibitor with anIC₅₀of 1.4 μM. NLS-StAx-h TFA efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h TFA shows anti-proliferation ofcancercells^[1]^[2].

IC₅₀& Target

IC₅₀: 1.4 μM (Wnt)^[1]

体外研究
(In Vitro)

NLS-StAx-h (10 μM; 72 h) inhibits proliferation of colorectal cancer cells^[1].
NLS-StAx-h (5 and 10 μM; 24 h) inhibits migration of colorectal cancer cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	SW-480 and DLD-1 cells
Concentration:	10 μM
Incubation Time:	72 hr
Result:	Reduced the viability of both SW-480 and DLD-1 by more than 80%.

Cell Migration Assay^[1]

Cell Line:	DLD-1 cells
Concentration:	5 and 10 μM
Incubation Time:	24 hr
Result:	Resulted in dose-dependent inhibition of wound closure (wound closure: 52% at 5 μM, and 24% at 10 μM).

分子量

3559.28

性状

Solid

Formula

C₁₆₂H₂₇₆F₃N₅₅O₃₁

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)