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Super-TDU
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1599441-71-0
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
Super-TDU 是一种特异性的YAP拮抗剂,可以靶向 YAP-TEAD 相互作用。Super-TDU 可以抑制胃癌小鼠模型的肿瘤生长。
生物活性

Super-TDU is a specificYAPantagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastriccancermouse model[1].

体外研究
(In Vitro)

Super-TDU downregulates expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27[1].

体内研究
(In Vivo)

Super-TDU (intravenous injection; 50 μg/kg or 500 μg/kg; per day) markedly decreases the sizes, weights of tumors, and YAP target genes in a dose-dependent manner in mice[1].
Super-TDU (intravenous injection; 250 μg/kg 500 μg/kg) has the t1/2αof 0.78 hours and 0.82 hours; the Cmaxof 6.12 ng/mL and 13.3 ng/mL; the CL of 7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively[1].

Animal Model:BALB/cA nu/nu mice[1]
Dosage:50 μg/kg or 500 μg/kg
Administration:Intravenous Injection; per day
Result:Decreased the sizes, weights of tumors, and YAP target genes in a dose-dependent manner.
Animal Model:BALB/cA nu/nu mice[1]
Dosage:250 μg/kg or 500 μg/kg (Pharmacokinetic Study)
Administration:Intravenous Injection
Result:The t1/2αis 0.78 hours and 0.82 hours; the Cmaxis 6.12 ng/mL and 13.3 ng/mL; the CL is7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively.
分子量

5279.94

性状

Solid

Formula

C237H370N66O69S

CAS 号

1599441-71-0

Sequence

Ser-Val-Asp-Asp-His-Phe-Ala-Lys-Ser-Leu-Gly-Asp-Thr-Trp-Leu-Gln-Ile-Gly-Gly-Ser-Gly-Asn-Pro-Lys-Thr-Ala-Asn-Val-Pro-Gln-Thr-Val-Pro-Met-Arg-Leu-Arg-Lys-Leu-Pro-Asp-Ser-Phe-Phe-Lys-Pro-Pro-Glu

Sequence Shortening

SVDDHFAKSLGDTWLQIGGSGNPKTANVPQTVPMRLRKLPDSFFKPPE

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 50 mg/mL(9.47 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM0.1894 mL0.9470 mL1.8940 mL
5 mM0.0379 mL0.1894 mL0.3788 mL
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 25 mg/mL (4.73 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。