HLY78

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HLY78

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

854847-61-3

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

HLY78 是 Lycorine (HY-N0288) 衍生物，是一种有效的Wnt/β-catenin信号通路的激活剂。HLY78 靶向于 Axin 的 DIX 结构域，促进 Axin-LRP6 的关联，从而促进 LRP6 磷酸化 (LRP6 phosphorylation) 和 Wnt 信号转导。HLY78 可用于蛛网膜下腔出血 (SAH) 的研究。

生物活性

HLY78, aLycorine(HY-N0288) derivative, is a potent activator of theWnt/β-cateninsignaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promotingLRP6 phosphorylationandWntsignal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research^[1]^[2]^[3].

IC₅₀& Target

Wnt/β-catenin^[1]

体外研究
(In Vitro)

HLY78 inhibitsapoptosisin tumor cells and embryonic cells caused by carbon ion radiation through activation of the Wnt/β-catenin pathway^[2].
HLY78 (20 μM, 0-48 h) significantly increases the colony formation ability by 2.78-fold and 2.88-fold for HGC-27 and AGS cells compared with the controls^[3].
HLY78 (20 μM, 0-48 h) elevates the migration ability of HGC-27 and AGS cells^[3].
HLY78 significantly increases TNKS expression, which is ameliorated byDihydroartemisinin(HY-N0176)^[3].

体内研究
(In Vivo)

HLY78 (0-1.8 mg/kg, Intranasal injection, once) attenuates neuronal apoptosis and improves neurological deficits through the LRP6/GSK3β/β-catenin signaling pathway after SAH (subarachnoid hemorrhage) in rats^[2].

Animal Model:	Adult male Sprague-Dawley rats (280-310 g, n=9/group, SAH model)^[2]
Dosage:	0, 0.2, 0.6, and 1.8 mg/kg
Administration:	Intranasal injection, once, at 1 h post-SAH (subarachnoid hemorrhage)
Result:	Significantly attenuated the short-term and long-term neurobehavioral deficits, as well as the neuronal apoptosis after SAH at 0.6 mg/kg. Successfully delivered into the brain via intranasal administration at 0.6 mg/kg and was sufficient to significantly increase the phosphorylation of LRP6. Reversed the changes of the Bcl-2, Bax, and cleaved caspase 3 levels.

分子量

267.32

性状

Solid

Formula

C₁₇H₁₇NO₂

CAS 号

854847-61-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 26 mg/mL(97.26 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.7408 mL	18.7042 mL	37.4083 mL
5 mM	0.7482 mL	3.7408 mL	7.4817 mL
10 mM	0.3741 mL	1.8704 mL	3.7408 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。