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(S)-(-)-5-Fluorowillardiine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(S)-(-)-5-Fluorowillardiine图片
CAS NO:140187-23-1
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
(S)-(-)-5-Fluorowillardiine 是一种有效且特异性的 AMPAR 激动剂。
Cas No.140187-23-1
别名5-氟代尿嘧啶丙氨酸; (5S)-Fluorowillardiine; (S)-5-Fluorowillardiine
化学名(S)-2-amino-3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid
Canonical SMILESFC1=CN(C(NC1=O)=O)C[C@@H](C(O)=O)N
分子式C7H8FN3O4
分子量217.16
溶解度Soluble to 50 mM in 1.1eq. NaOH
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist.

References:
[1]. Hawkinson JE, et al. Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine, (S)-AMPA and (R,S)-AMPA binding. Eur J Pharmacol. 1997 Jun 25;329(2-3):213-21.
[2]. Kessler M, et al. Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators. Brain Res. 2006 Mar 3;1076(1):25-41.
[3]. Rembach A, et al. Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. J Neurosci Res. 2004 Aug 15;77(4):573-82.