ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation^[1][2].

ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs^[3].
ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner^[4].
ATP promotes neutrophil chemotaxis in vitro^[4].

ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo^[4].
ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo^[4].

507.18

Solid

C₁₀H₁₆N₅O₁₃P₃

56-65-5

腺苷三磷酸

• Alkaloids
• Other Alkaloids

• Plants
• other families

widespread

Room temperature in continental US; may vary elsewhere.

H₂O : ≥ 100 mg/mL(197.17 mM)

*"≥" means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 100 mg/mL (197.17 mM); Clear solution; Need ultrasonic and warming and heat to 60℃