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Nivolumab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:946414-94-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
25mg电议
50mg电议

产品名称
纳武单抗
BMS-936558
ONO-4538
MDX-1106
产品介绍
Nivolumab 是一种PD-1人源类 IgG4 抗体类抑制剂,用于晚期(转移性)非小细胞肺癌的研究。
生物活性

Nivolumab is a programmed death receptor-1 (PD-1) blocking humanIgG4antibody to treat advanced (metastatic) non-small cell lungcancer.

体外研究
(In Vitro)

Nivolumab binds to CHO cells expressing PD-1 with an EC50of 1.66 nM, but does not bind to the parental CHO cell line. Nivolumab binds to PD-1 on activated T cells with an EC50of 0.64 nM. Nivolumab also inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2, with IC50values of 2.52 and 2.59 nM, respectively. Nivolumab (1.5 ng/mL) can enhance T-cell reactivity in the presence of a T-cell receptor stimulus[1].

体内研究
(In Vivo)

Nivolumab (10 and 50 mg/kg, i.v.) is well tolerated in cynomolgus monkeys. Serum chemistry changes are limited to a reversible 28% decrease in T3 at week 13 in females treated with 50 mg/kg. T4 and TSH levels are unchanged. In males treated with 50 mg/kg, there are no changes in T3, T4, or TSH levels. Nivolumab exposure increases in an approximately dose-proportional manner between 10 and 50 mg/kg, with no substantial sex differences noted[1].

Clinical Trial
分子量

143599.09

性状

Liquid

CAS 号

946414-94-4

中文名称

纳武单抗;尼鲁单抗

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.