EGTA

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EGTA

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

67-42-5

包装与价格：

包装	价格(元)
500mg	电议
1 g	电议
5 g	电议
10 g	电议

产品介绍

EGTA 是一种特殊的钙离子螯合剂。EGTA 在生理 pH 值 (7.4) 下，K_d为 60.5 nM，对 Ca²⁺比对 Mg²⁺有很高的特异性。EGTA 显著抑制炎性巨噬细胞的底物粘附能力。

生物活性

EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (K_d) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca²⁺over Mg²⁺(Mg²⁺K_d1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages^[1]^[2].

体外研究
(In Vitro)

EGTA, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA concentration that causes an IC₅₀is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules^[2].

分子量

380.35

性状

Solid

Formula

C₁₄H₂₄N₂O₁₀

CAS 号

67-42-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 5 mg/mL(13.15 mM;ultrasonic and warming and adjust pH to 9 with NaOH and heat to 60℃)

DMSO : 1 mg/mL(2.63 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.6292 mL	13.1458 mL	26.2916 mL
5 mM	0.5258 mL	2.6292 mL	5.2583 mL
10 mM	0.2629 mL	1.3146 mL	2.6292 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。