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β-Nicotinamide mononucleotide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
β-Nicotinamide mononucleotide图片
CAS NO:1094-61-7
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议
1 g电议
5 g电议
10 g电议

产品名称
烟酰胺单核苷酸
β-NM
NMN
产品介绍
β-nicotinamide mononucleotide (β-NM) 是烟酰胺磷酸核糖转移酶 (NAMPT) 反应的产物,NAD+的关键中间体。β-nicotinamide mononucleotide 的作用包括其在细胞生化功能、心脏保护、糖尿病、阿尔茨海默病和肥胖相关并发症中的作用。
生物活性

β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity[1].

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

β-nicotinamide mononucleotide has several beneficial pharmacological activities. Mostly mediated by its involvement in NAD+biosynthesis, the pharmacological activities of NMN include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity[1].
The intracellular NAD+levels are significantly decreased by knockdown or knockout of Nampt (Nampt KD or Nampt KO) or treatment with Nampt inhibitor FK866, whereas NAD+levels are dramatically increased by supplement of NAD+precursors NAM or NMN (0.5-1 mM). NAD+precursor NMN treatment inhibited CD8+T cells activation and function[2].

体内研究
(In Vivo)

β-Nicotinamide mononucleotide (500 mg/kg; i.p.; 3 times per week for 7-10 week) prevents mtDNA damage and Dox-induced cardiac dysfunction[3].
Nampt KO markedly inhibits tumor progression, whereas Nampt metabolite β-Nicotinamide mononucleotide (300 mg/kg body weight; i.p.; once every two days for 2 weeks) significantly promotes tumor growth in C57BL/6 mice (bearing wildtype Hepa1-6 cells). The reduction and increase in NAD+level of respective Nampt KO and β-Nicotinamide mononucleotide-treated tumors are confirmed[2].
β-nicotinamide mononucleotide ameliorates glucose intolerance by restoring NAD+levels in HFD-induced T2D mice. β-nicotinamide mononucleotide also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation[4].

Animal Model:C57BL6 mice (p53–/–mice)[3]
Dosage:500 mg/kg
Administration:I.p.; 3 times per week for 7-10 week
Result:Prevented the significant decline in cardiac function of Dox-treated p53–/–mice (study week 7 versus 10) along with rescuing the decreased mitochondrial respiration and tissue ATP depletion caused by Doxorubicin (Dox).
分子量

334.22

性状

Solid

Formula

C11H15N2O8P

CAS 号

1094-61-7

中文名称

β-烟酰胺单核苷酸;烟酰胺单核苷酸

结构分类
  • Ketones, Aldehydes, Acids
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

H2O : 83.33 mg/mL(249.33 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.9920 mL14.9602 mL29.9204 mL
5 mM0.5984 mL2.9920 mL5.9841 mL
10 mM0.2992 mL1.4960 mL2.9920 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 100 mg/mL (299.20 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。