Janelia Fluor(R) 669, SE (JF669, SE), a redfluorescent dye, can be directly reacted with the available thiol-containing HaloTag ligand under mild conditions (DIEA, DMF) to afford a JF669–HaloTag ligand in a single step (Ex = 669 nm; Em = 682 nm)^[1]. Janelia Fluor(R) products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

JF669 undergoes rapid conversion to thioether product (<5 min to completion) in organic solvents, where the dye predominantly adopts closed form^[1].
JF669 displays comparatively excellent photostability, retaining 97% fluorescence after the same number of cycles^[1].

693.76

C₃₄H₃₀F₃N₃O₆SSi

2127150-20-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.