CAS NO: | 4707-32-8 |
包装 | 价格(元) |
10 mM * 1 mL in Ethanol | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as atopoisomeraseIinhibitor, and inducesapoptosisby inhibiting cell cycle progression. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | β-Lapachone is a topoisomerase I inhibitor. β-Lapachone (25 μM) inhibits camptothecin-induced DNA cleavage[1]. β-Lapachone (10-40 μM) significantly reduces the colony-forming ability of CHO cells, and is cytotoxic in S phase. β-Lapachone at above 10 μM, causes a heavy DNA-strand breaks in CHO cells[2]. β-Lapachone (10 μM) suppresses JCPyV replication in IMR-32 cells. β-Lapachone (1.0 μM) potently affects JCPyV propagation in JCI cells. β-Lapachone (0.01-0.1 μM) inhibits VP1 production in JCI cells[4]. | ||||||||||||||||
体内研究 (In Vivo) | β-Lapachone (0.066%) ameliorates cisplatin-induced renal injury and when in combination with cisplatin, the affect is more significant in mice. β-Lapachone increases Mre11-Rad50-Nbs1 (MRN) complex expression in mice[3]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 242.27 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C15H14O3 | ||||||||||||||||
CAS 号 | 4707-32-8 | ||||||||||||||||
中文名称 | β-拉帕醌 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 25 mg/mL(103.19 mM;Need ultrasonic) Ethanol : 8.33 mg/mL(34.38 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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