您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Rhein
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Rhein
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rhein图片
CAS NO:478-43-3
包装与价格:
包装价格(元)
100mg电议
200mg电议
500mg电议
1 g电议
5 g电议

产品名称
大黄酸
Rheic Acid
Rhubarb yellow
Monorhein
产品介绍
Rhein 是一种蒽醌类化合物,具有抗炎、抗氧化、抗癌等作用。
生物活性

Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. IC50 value: Target: In vitro: Rhein (0.1 and 1 mg/mL) evidently suppressed cell proliferation and mitogen-activated protein (MAP) kinase activation in human colon adenocarcinoma cells (Caco-2) but significantly lessened H2O2-induced DNA damage and the elevated MDA and ROS levels induced by H2O2/Fe2+ at the concentrations of 0.1–10 mg/mL [1]. In vivo: Oral administration of rhein (150 mg/kg/d) evidently ameliorated renal interstitial fibrotic lesions and attenuated the expression of α-SMA and deposition of fibronectin (FN) in mice with renal interstitial fibrosis induced by unilateral ureteral obstruction. Rhein also suppressedTGF-β1and its type I receptor expression in obstructed kidneys [1]. The biochemical parameters results of IgAN model rats showed that rhein-prevented and rhein-treated both improved the biochemical parameters and relieved renal pathological injury. The expressions of renal tissueTLR4,TGF-β1, but notTLR9were significantly elevated in IgAN model rats (P< 0.05). Rhein-prevented and rhein-treated both inhibitedTLR4andTGF-β1expressions [2].

分子量

284.22

性状

Solid

Formula

C15H8O6

CAS 号

478-43-3

中文名称

大黄酸

结构分类
  • Quinones
  • Anthraquinones
  • Phenols
  • Polyphenols
来源
  • Plants
  • Polygonaceae
  • Rheum palmatumL.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

0.1 M NaOH : ≥ 12.5 mg/mL(43.98 mM)

DMSO : 12.17 mg/mL(42.82 mM;Need ultrasonic and warming)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.5184 mL17.5920 mL35.1840 mL
5 mM0.7037 mL3.5184 mL7.0368 mL
10 mM0.3518 mL1.7592 mL3.5184 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40%PEG300   5%Tween-80   45% saline

    Solubility: 1.67 mg/mL (5.88 mM); Suspended solution; Need ultrasonic

    此方案可获得 1.67 mg/mL (5.88 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 16.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH2O 中,得到澄清透明的生理盐水溶液
*以上所有助溶剂都可在本网站选购。