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L-Histidine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Histidine图片
CAS NO:71-00-1
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
500mg电议
1 g电议
5 g电议
10 g电议

产品名称
L-组氨酸
产品介绍
L-Histidine 是婴儿必需的氨基酸。L-Histidine 是线粒体谷氨酰胺转运的抑制剂。
生物活性

L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor ofmitochondrial glutamine transport.

IC50& Target

Human Endogenous Metabolite

 

Microbial Metabolite

 

体外研究
(In Vitro)

L-histidine completely inhibits growth and its effect on viability is inversely related toFLO11expression. L-histidine does not affect the viability of theΔflo11and S288c strains. L-histidine dramatically decreases air-liquid biofilm formation and adhesion to polystyrene of the flor yeasts with no effect on the transcription level of theFLO11gene. Moreover, L-histidine modifies the chitin and glycans content on the cell-wall of flor yeasts[1].

体内研究
(In Vivo)

L-histidine (100 mg/kg) completely inhibits the brain edema in thioacetamide-treated rats[2]. Histamine release stimulated by high K+from the hypothalamus in the L-histidine diet group is 60% of that in the control group. However, the concentrations of other monoamines and their metabolites are not changed by the L-histidine diet. The open-field tests show that the L-histidine diet group spends a shorter amount of time in the central zone, and the light/dark box tests demonstrate that the L-histidine diet group spends a shorter amount of time in the light box, suggesting that the L-histidine diet induced anxiety-like behaviors[3].

Clinical Trial
分子量

155.15

性状

Solid

Formula

C6H9N3O2

CAS 号

71-00-1

中文名称

L-组氨酸

结构分类
  • Amino acids
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

H2O : 20.83 mg/mL(134.26 mM;ultrasonic and warming and heat to 80℃)

DMSO : 1 mg/mL(6.45 mM;ultrasonic and warming and heat to 80℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM6.4454 mL32.2269 mL64.4538 mL
5 mM1.2891 mL6.4454 mL12.8908 mL
10 mM0.6445 mL3.2227 mL6.4454 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 25 mg/mL (161.13 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。