Dimethyl malonate

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Dimethyl malonate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

108-59-8

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
500mg	电议
1 g	电议
5 g	电议

产品名称

丙二酸二甲酯

产品介绍

Dimethyl malonate 是琥珀酸脱氢酶 (SDH) 的竞争性抑制剂。Dimethyl malonate 能够穿过血脑屏障水解成丙二酸酯。Dimethyl malonate 减少神经元凋亡 (apoptosis)。

生物活性

Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronalapoptosis^[1].

体内研究
(In Vivo)

Dimethyl malonate (6 mg/kg/min; intravenous infusion; 51 min) promotes return of spontaneous circulation (ROSC) and neurological performance in rats after cardiac arrest^[1].

Animal Model:	Sprague-Dawley male rats, cardiac arrest model^[1]
Dosage:	6 mg/kg/min
Administration:	Intravenous infusion, 51 min
Result:	Improved ROSC after CA. Prevented the decline in neurological function and inhibited the apoptosis of hippocampal neurons at day 3 after CPR. Inhibited caspase-3 cleavage and increased HIF-1α expression at day 3 after CPR. Decreased the level of oxidative stress at day 3 after CPR. Inhibited excessive hyperpolarization of MMP and restrained the leakage of cytochrome C after 45 min reperfusion.

Clinical Trial

分子量

132.11

性状

Liquid

Formula

C₅H₈O₄

CAS 号

108-59-8

中文名称

丙二酸二甲酯

结构分类

Others

来源

Plants
Meliaceae
Melia azedarach L.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(756.94 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	7.5694 mL	37.8472 mL	75.6945 mL
5 mM	1.5139 mL	7.5694 mL	15.1389 mL
10 mM	0.7569 mL	3.7847 mL	7.5694 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。