您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Meropenem
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Meropenem
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Meropenem图片
CAS NO:96036-03-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
美罗培南
SM 7338
产品介绍
Meropenem (SM 7338) 是一种具有广谱抗菌活性的碳青霉烯抗生素。Meropenem 对敏感和耐药的淋病奈瑟氏球菌 (MIC 值为 0.02-0.06 mg/mL),流感嗜血杆菌 (MIC 值为 0.03-0.12 mg/mL) 和杜克氏杆菌 (MIC 值为 0.015-0.12 mg/mL) 具有活性。
生物活性

Meropenem (SM 7338) is a carbapenemantibioticwith broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistantN. gonorrhoeae(MIC value of 0.02-0.06 mg/mL),H. influenzae(MIC value of 0.03-0.12 mg/mL), andH. ducreyi(MIC value of 0.015-0.12 mg/mL)[1][2].

体外研究
(In Vitro)

Meropenem is intrinsically stable to dehydropeptidase-1 (DHP-1) degradation and Meropenem acts by inhibiting bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBPs). Meropenem possesses broad-spectrum in vitro activity, which includes activity against many Gram-positive, Gram-negative and anaerobic bacteria; Meropenem lacks activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus and Stenotrophomonas maltophilia[2].

体内研究
(In Vivo)

Meropenem (60 mg/kg; intraperitoneal injection; once; SD rats) treatment significantly reduces the incidence of pancreatic infection[3].

Animal Model:Male Sprague-Dawley rats (250-350 g) induced acute necrotizing pancreatitis[3]
Dosage:60 mg/kg
Administration:Intraperitoneal injection; once
Result:Significantly reduced the incidence of pancreatic infection.
Clinical Trial
分子量

383.46

Formula

C17H25N3O5S

CAS 号

96036-03-2

中文名称

美罗培南;美洛培南

结构分类
  • Antibiotics
  • Beta-lactam Antibiotics
来源

aerobes and anaerobes

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.