Delafloxacin

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Delafloxacin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

189279-58-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

德拉沙星
RX-3341
WQ-3034
ABT492

产品介绍

Delafloxacin (RX-3341; WQ-3034; ABT492) 是一种广谱氟喹诺酮类抗生素。Delafloxacin 具有广泛的活性，对耐药性的金黄色葡萄球菌，肺炎链球菌和肺炎克雷伯菌都有效。

生物活性

Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinoloneantibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistantStaphylococcus aureus,Streptococcus pneumoniae, andKlebsiella pneumonia^[1].

IC₅₀& Target

Quinolone

体内研究
(In Vivo)

Delafloxacin (the total daily doses vary from 0.156 to 640 mg/kg/24 h, subcutaneous injection) is highly effective againstS. aureus. Against all four strains are observed a decrease of 1.5 to 2.2 log₁₀CFU in organism burden from untreated controls at even the lowest dose studied, and for two strains (MW2 and R2527) there is net bactericidal activity at the lowest dose. At the maximal doses studied, there is a >4-log₁₀kill from initial burden for allS. aureusstrains^[1].
Delafloxacin (2.5, 10, 40, and 160 mg/kg; subcutaneous injection, 24 h) has moderate terminal elimination half-life (t_1/2=0.68 h, 0.79 h, 0.69 h and 1.0 h for 2.5 mg/kg, 10 mg/kg, 40 mg/kg, and 160 mg/kg, respectively)^[1].

Animal Model:	Mice with a neutropenic murine lung infection model (fourS. aureus, fourS. pneumoniae, and fourK. pneumoniaestrains)^[1]
Dosage:	The total daily doses vary from 0.156 to 640 mg/kg/24 h
Administration:	0.03 to 160 mg/kg are administered every 6 h (q6h) to infected mice by subcutaneous injection
Result:	InhibitedS. aureusstrains ATCC 29213, ATCC 33591, MW2, R2527 with MICs of 0.008, 0.008, 0.004, and 0.004 mg/L, respectively. InhibitedS. pneumoniaestrains ATCC 10813, ATCC 49619, 145, and 1329 with MICs of 0.03, 0.125, 0.016, and 0.016 mg/L, respectively. InhibitedK. pneumoniastrains ATCC 43816, 4105, 4110, and 81-1260A with MICs of 0.06, 1, 0.5, and 0.06 mg/L, respectively.

Animal Model:	Neutropenic mice^[1]
Dosage:	2.5, 10, 40, and 160 mg/kg; 0.2 mL
Administration:	Subcutaneous injection; 24 h
Result:	The maximum drug concentrations (C_max) concentrations ranged from 2 to 71 mg/L. AUC_0-∞values ranged from 2.8 to 152 mgoh/L and were linear across the 2.5- to 160-mg dosing range. The elimination half-life (t_1/2) ranged from 0.7 to 1 h.

Clinical Trial

分子量

440.76

Formula

C₁₈H₁₂ClF₃N₄O₄

CAS 号

189279-58-1

中文名称

德拉沙星

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.