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Oxytocin Acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Oxytocin Acetate图片
CAS NO:6233-83-6
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议
1 g电议
5 g电议

产品名称
醋酸催产素
醋酸缩宫素
α-Hypophamine acetate
Oxytocic hormone acetate
产品介绍
Oxytocin (α-Hypophamine) acetate 是一种多效的下丘脑肽 (hypothalamic peptide),有助于分娩、哺乳和亲社会行为。Oxytocin acetate 可以作为一种压力应对分子,具有抗炎、抗氧化剂和保护作用,特别是在面对逆境或创伤时。
生物活性

Oxytocin (α-Hypophamine) acetate is a pleiotropic,hypothalamic peptideknown for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma[1][2].

IC50& Target

Human Endogenous Metabolite

 

体内研究
(In Vivo)

During the LMA task, rat core body temperature are modestly decreased. Oxytocin acetate (subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose) produces significantly greater hypothermia (at 0.3 mg/kg) than either saline or the two lower doses of oxytocin. Oxytocin at 0.3 mg/kg produces a significantly greater decrease in temperature than vehicle between 15-60 min post injection, whereas 0.1 mg/kg slightly decreases temperature at the 30 min time point only[1].
Oxytocin acetate (0.1 mg/kg) engages in significantly more body sniffing and ano-genital sniffing compared with saline controls. It also increases the total time spent in social interaction (71.6±4.3 s), compared to those receiving vehicle (56.9±4.1 s)[1].

Animal Model:Fifty-six male Lister-hooded rats (150–200 g)[1]
Dosage:0.1 mg/kg-0.3 mg/kg
Administration:Subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose
Result:Produced significantly greater hypothermia (at 0.3 mg/kg) than the saline group.
Clinical Trial
分子量

1067.24

性状

Solid

Formula

C45H70N12O14S2

CAS 号

6233-83-6

Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge:Cys1-Cys6)

Sequence Shortening

CYIQNCPLG-NH2 (Disulfide bridge:Cys1-Cys6)

中文名称

醋酸催产素;醋酸缩宫素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 50 mg/mL(46.85 mM;Need ultrasonic)

DMSO : ≥ 44 mg/mL(41.23 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM0.9370 mL4.6850 mL9.3700 mL
5 mM0.1874 mL0.9370 mL1.8740 mL
10 mM0.0937 mL0.4685 mL0.9370 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 25 mg/mL (23.42 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。