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GnRH-I
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
GnRH-I 是一种十肽,源于下丘脑,主要通过调节 GnRH 受体 (GnRHR) 介导的垂体部位有生物活性的促卵泡激素 (FSH)、促黄体激素 (LH) 的释放而发挥作用。
生物活性

GnRH-I is a decapeptide of hypothalamic origin. GnRH-I acts primarily by regulating the release of biologically active follicle stimulating hormone (FSH) and luteinising hormone (LH) from the pituitary site mediated by theGnRH receptor(GnRHR)[1][2].

体外研究
(In Vitro)

GnRH-I (0.001-10 μM, 72 h) leads to a significant increase in cell proliferation of PMBC cell lines. Moreover, cells co-treated with IL-2 (50 U/mL) and GnRH-I exhibits a higher proliferative response than IL-2 treatment alone[1].
GnRH-I (0.001-10 μM, 24 h) can effectively increase the expression of IL-2R mRNA of 162.3% compared to the control group in PMBCs[1].
GnRH-I (10 nM, 3 h) can be expressed in human T cells and activates T cell production of laminin receptors while induces chemotaxis of normal human T cells to a key chemokine, stromal cell-derived factor-1α, through a lamina-coated filter[2].
GnRH-I (10 nM, 72 h) significantly increases the migration of EL-4 t -lymphoma cells to the bone marrow and spleen of mice, but does not increase the migration of EL-4 to the thymus, kidney and liver, nor does it increase the number of EL-4 cells in plasma[3].

分子量

1182.32

性状

Solid

Formula

C50H75N17O13

Sequence

Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Sequence Shortening

Pyr-HWSYGLRPG-NH2

结构分类
  • Others
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O : 50 mg/mL(42.29 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM0.8458 mL4.2290 mL8.4579 mL
5 mM0.1692 mL0.8458 mL1.6916 mL
10 mM0.0846 mL0.4229 mL0.8458 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 100 mg/mL (84.58 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。