CAS NO: | 2244678-29-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | TH-257 is a potent inhibitor ofLIMK1andLIMK2withIC50values of 84 nM and 39 nM forLIMK1andLIMK2, respectively, and it can be used as a chemical probe forLIMK1andLIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | TH-257 exhibits good biochemical and cellular potencies. But its extremely rapid in vitro clearance renders it unsuitable as a potential in vivo tool[2]. | ||||||||||||||||
分子量 | 422.54 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H26N2O3S | ||||||||||||||||
CAS 号 | 2244678-29-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 250 mg/mL(591.66 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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