TH470

立即咨询

TH470

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2834739-51-2

包装与价格：

产品介绍

TH470 是一种高选择性的LIMK1/2(LIM 激酶 1/2) 抑制剂 (LIMK1IC₅₀=9.8 nM; LIMK2IC₅₀=13 nM)，可用于孤儿病的研究。

生物活性

TH470 is a highly selectiveLIMK1/2(LIM kinase1/2) inhibitor (LIMK1IC₅₀=9.8 nM;LIMK2IC₅₀=13 nM), and can be used in orphan disease research^[1].

IC₅₀& Target^[1]

LIMK1

9.8 nM (IC₅₀)

LIMK2

13 nM (IC₅₀)

体外研究
(In Vitro)

TH470 (0.05-5 μM; 12 h) inhibits the growth of neurite^[1].

Cell Viability Assay^[1]

Cell Line:	N1E-115 cells transfected with siRNAs against FMR1 (siFMR1) or control siRNAs (siCtr)
Concentration:	0.05, 0.5, or 5 μM
Incubation Time:	12 hours
Result:	Inhibited neurite outgrowth in a dose-dependent manner.

分子量

605.73

Formula

C₃₀H₃₁N₅O₅S₂

CAS 号

2834739-51-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.