包装 | 价格(元) |
10 mM * 1 mL in Water | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite ofFludarabine(HY-B0069), is a potent, noncompetitive and specific inhibitor ofDNA primase, with anIC50of 2.3 μM and aKiof 6.1 μM. Fludarabine triphosphate trisodium inhibitsDNA synthesisby blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellularapoptosis[1][2]. | ||||||||||||||||
IC50& Target | IC50: 2.3 ± 0.3 μM (DNA primase); Ki: 6.1 ± 0.3 μM (DNA primase)[1] | ||||||||||||||||
体外研究 (In Vitro) | Fludarabine triphosphate trisodium is a more potent inhibitor of the polydeoxythymidylate primase activity than of the DNA polymerase α/δ activities present in the supernatants of CCRF-CEM cells[1]. | ||||||||||||||||
分子量 | 591.12 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C10H12FN5Na3O13P3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | -20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 125 mg/mL(211.46 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |