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Thiotepa(STEPA TESPA)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thiotepa(STEPA TESPA)图片
CAS NO:52-24-4
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
Thiotepa or Thio-TEPA (NSC-6396; AI3 24916; WR45312; Girostan), an approved drug for cancer treatment, is a potent DNA alkylating agent with antitumor activity. Thiotepa is a polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth.
理化性质和储存条件

Name: Thiotepa
CAS#: 52-24-4
Chemical Formula: C6H12N3PS
Exact Mass: 189.04895
Molecular Weight: 189.22
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Technical InformationSynonym: NSC-6396; AI3 24916; WR45312; NSC 6396; AI324916; WR 45312; NSC6396; AI3-24916; Girostan; thiophosphoramide; thiophosphamide; triethylene thiophosphoramide. trade names: Girostan; STEPA; TESPA; Thiofozil; Thioplex; Tifosyl. Foreign brand names: Ledertepa; Oncotiotepa; Onco Tiotepa; Tespamin; Tespamine; Thiotef; TioTEF; TSPA; WR45312.
Chemical Name: tri(aziridin-1-yl)phosphine sulfide
InChi Key: FOCVUCIESVLUNU-UHFFFAOYSA-N
InChi Code: InChI=1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
SMILES Code: S=P(N1CC1)(N2CC2)N3CC3