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ONO-8130
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ONO-8130图片
CAS NO:459841-96-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
ONO-8130 是一种口服有效和选择性的前列腺素 EP1 受体 (EP1 receptor) 拮抗剂。ONO-8130 可阻断 L6 脊髓中ERK的磷酸化。ONO-8130 可减轻环磷酰胺致膀胱炎小鼠的膀胱疼痛。ONO-8130 可用于间质性膀胱炎的研究。
生物活性

ONO-8130 is an orally active and selective prostanoidEP1 receptorantagonist. ONO-8130 blocks phosphorylation ofERKin the L6 spinal cord. ONO-8130 relieves bladder pain in mice with cyclophosphamide-induced cystitis. ONO-8130 can be used for interstitial cystitis research[1].

体内研究
(In Vivo)

ONO-8130 (0.3-30 mg/kg; Oral preadministration, once) strongly prevents both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent manner[1].
ONO-8130 (30 mg/kg; Orally, once) reverses the established cystitis-related bladder pain[1].
ONO-8130 (30 mg/kg; Orally, once) strongly inhibits phosphorylation of ERK in MDH, DCM, and SPN of the L6 spinal cord caused by intravesical administration of PGE2[1].

Animal Model:Female ddY mice (18-22 g, 4-5 weeks old)[1]
Dosage:0.3, 3, 10, and 30 mg/kg
Administration:Orally, once
Result:Strongly prevented both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent manner, but had slight effect on the increased bladder weight and vascular permeability.
Animal Model:Female ddY mice (18-22 g, 4-5 weeks old, established bladder pain caused by IP cyclophosphamide)[1]
Dosage:10, 30 mg/kg
Administration:Orally, once (administered 2.75 hours after i.p. cyclophosphamide)
Result:Markedly attenuated the bladder pain-like nociceptive behavior and referred hyperalgesia in the acute phase (3.5-4 h after cyclophosphamide).
Animal Model:Female ddY mice (18-22 g, 4-5 weeks old, established bladder pain caused by IP cyclophosphamide)[1]
Dosage:30 mg/kg
Administration:Orally, once (administered 4.75 hours after i.p. cyclophosphamide)
Result:Significantly suppressed the bladder pain-like nociceptive behavior and tended to reduce the referred hyperalgesia in the persistent phase, 5.5-6 hours after cyclophosphamide.
Animal Model:Female ddY mice (18-22 g, 4-5 weeks old, intravesical administration of PGE2 at 5 nmol/mouse)[1]
Dosage:30 mg/kg
Administration:Orally, once
Result:Strongly inhibited phosphorylation of ERK in MDH, DCM, and SPN of the L6 spinal cord caused by intravesical administration of PGE2 at 5 nmol/mouse, exerted complete blockade in DCM, while its inhibitory effects in MDH and SPN were partial.
分子量

500.63

Formula

C25H28N2O5S2

CAS 号

459841-96-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.