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Indimitecan
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Indimitecan图片
CAS NO:915360-05-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品名称
LMP776
产品介绍
Indimitecan (LMP776) 是一种拓扑异构酶 I (Top1) 抑制剂,具有抗癌活性。
生物活性

Indimitecan (LMP776) is atopoisomeraseI (Top1) inhibitor with anticancer activities[1].

IC50& Target

Top1

 

体外研究
(In Vitro)

Indimitecan (LMP776) (0-100 μM) shows antiproliferative potencies against various human cancer cell lines, with mean-graph midpoint (MGM) of 0.079 ± 0.023 μM[1].
Indimitecan shows potent DNA cleavage due to Top1 inhibition[1].
Indimitecan can be substrates for metabolic ketone reductases[1].

Cell Proliferation Assay[1]

Cell Line:HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145, MCF-7
Concentration:0-100 μM
Incubation Time:
Result:Showed growth inhibition with GI50s of<0.01,<0.01, 0.04,<0.01, 0.08,<0.01,<0.01 and 0.01 μM against HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145 and MCF-7 cells, respectively. And the mean-graph midpoint (MGM) for growth inhibition of all human cancer cell lines successfully tested (the National Cancer Institute’s developmental therapeutics assay (the “NCI60”)) was 0.079 ± 0.023 μM.
Clinical Trial
分子量

459.45

性状

Solid

Formula

C25H21N3O6

CAS 号

915360-05-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 8.33 mg/mL(18.13 mM;ultrasonic and warming and adjust pH to 3 with HCl and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.1765 mL10.8826 mL21.7652 mL
5 mM0.4353 mL2.1765 mL4.3530 mL
10 mM0.2177 mL1.0883 mL2.1765 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。