Seconeolitsine, anantibiotic, and is an inhibitor of targetingtopoisomeraseI (TopA). Seconeolitsine also is a new antimicrobial agent that can inhibitS. pneumoniaegrowth. Seconeolitsine can inhibit TopA relaxation activity with anIC₅₀value of 17 μM. Seconeolitsine can be used for the research ofS. pneumoniaeinfections resistant toother antibiotics^[1].

Seconeolitsine (compounds 17) inhibits TopA relaxation activity in a concentration-dependent manner, with an IC₅₀value of 17 μM and the inhibition of TopA is enhanced by preincubation of the enzyme with the alkaloid^[1].
Seconeolitsine shows great inhibition ofS.pneumoniaegrowth with MIC₅₀values of 16 μM for R6, ATCC6303, CipS8, CipS9, CipR20, CipR16, CipR8, CipR45 and CipR5. And shows great inhibition ofS. pneumoniaegrowth with MIC₅₀values of 8 μM for CipR42, CipR68 and CipR15^[1].
Seconeolitsine has activation at low concentrations and partial inhibition at 50 μM, a concentration at which the pneumococcal TopA showed full inhibition, but not inhibits Human TOPO1^[1].
Seconeolitsine (0.25×-1×MIC) affects cell growth and division in a concentration-dependent manner^[1].
Seconeolitsine (30 and 100 μM), is not affected neutrophil apoptosis and human cell viability^[1].

Seconeolitsine (compounds 17) increases supercoiling and TopA is target in vivo^[1].

323.34

C₁₉H₁₇NO₄

2650074-56-7

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