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Pomalidomide-C3-adavosertib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pomalidomide-C3-adavosertib图片
CAS NO:2414418-49-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Pomalidomide-C3-adavosertib 是一种快速和选择性的Wee1降解剂 (IC50=3.58 nM)。Pomalidomide-C3-adavosertib 具有抗癌细胞增殖活性,并能诱导细胞凋亡。
生物活性

Pomalidomide-C3-adavosertib is a rapid and selectiveWee1degrader (IC50=3.58 nM). Pomalidomide-C3-adavosertib shows anti-cancer cell proliferation activity, and inducesapoptosis[1].

体外研究
(In Vitro)

Pomalidomide-C3-adavosertib (1 nM-10 μM; 24, 48, and 72 h) induces CRBN-dependent anti-proliferative effects and synergized with Olaparib[1].
Pomalidomide-C3-adavosertib (100 nM; 24 h) induces DNA damage, apoptosis, and deregulation of the G2/M checkpoint[1].
Pomalidomide-C3-adavosertib (1 nM-10 μM; 6 h) degrades Wee1 in MOLT4 cells[1].

Cell Proliferation Assay[1]

Cell Line:OVCAR8, COV362, and Kuramochi cells
Concentration:1 nM-10 μM
Incubation Time:24, 48, and 72 hours
Result:Degraded Wee1 in OVCAR8 cells, with maximal degradation observed at a 100 nM treatment.

Cell Cycle Analysis[1]

Cell Line:MOLT4 cells
Concentration:100 nM
Incubation Time:24 hours
Result:Led to reduced pCDKl Y15, increased apoptosis, and increased unrepaired DNA.

Western Blot Analysis[1]

Cell Line:MOLT4 cells
Concentration:1 nM-10 μM
Incubation Time:6 hours
Result:Degraded Wee1 after a 6-hour treatment in MOLT4 cells, and induced the downstream changes expected from Wee1 loss-including a decrease in phosphorylated cyclin-dependent kinase 1 (pCDK1) and an increase in pH 3.
分子量

799.88

Formula

C42H45N11O6

CAS 号

2414418-49-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.