LEB-03-146 是一个WEE1DUBTAC (去泛素化酶靶向嵌合体)，通过 PEG2 连接剂将 AZD1775 (Adavosertib) 与 OTUB1 招募者 EN523 连接起来。LEB-03-146 在 HEP3B 肝癌细胞中可显著稳定WEE1。
| 生物活性 | LEB-03-146 is aWEE1DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to theOTUB1recruiter EN523 through a PEG2 linker. LEB-03-146 shows significantWEE1stabilization in HEP3B hepatomacancercells[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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