CAS NO: | 1321514-06-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | AZD4635 (HTL1071) is a potent, selective and orally activeadenosine A2A receptor(A2AR) antagonist. AZD4635 binds tohuman A2ARwith aKiof 1.7 nM and shows >30-fold selectivity over other adenosine receptors[1]. | ||||||||||||||||
IC50& Target | Ki: 1.7 nM (A2AR)[1] | ||||||||||||||||
体外研究 (In Vitro) | In the presence of 0.1, 1 and 10 μM adenosine, the IC50s of AZD4635 for inhibition of cAMP production are 0.79, 10.0 and 142.9 nM, respectively[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 315.73 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C15H11ClFN5 | ||||||||||||||||
CAS 号 | 1321514-06-0 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 83.3 mg/mL(263.83 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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