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Resolvin D4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Resolvin D4图片
CAS NO:1025684-60-9
包装与价格：
包装价格(元)
10μg电议
25μg电议
50μg电议
100μg电议

产品介绍

Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid.

Cas No.1025684-60-9
别名RvD4
化学名4S,5,17S-trihydroxy-6E,8E,10E,13E,15Z,19Z-docosahexaenoic acid
Canonical SMILESO[C@@H]([C@@H](O)CCC(O)=O)/C=C/C=C/C=C\C/C=C\C=C\[C@@H](O)C/C=C\CC
分子式C22H32O5
分子量376.5
溶解度50 mg/ml in DMF, 50 mg/ml Ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid . [1] It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreated tissues from humans, mice, and sardines.[2][3] RvD4, at 10 ng/mouse, reduces neutrophil infiltration in zymosan A-induced peritonitis and, at 200 ng/mouse, diminishes neutrophil infiltration in response to S. aureus infection. [3] With isolated cells, RvD4 promotes phagocytosis of bacteria, opsonized zymosan A, and apoptotic neutrophils by human macrophages.[3] It also promotes the clearance of apoptotic neutrophils by human fibroblasts.[3]

Reference：
[1]. Serhan, C.N., and Savill, J. Resolution of inflammation: The beginning programs the end. Nature Immunology 6(12), 1191-1197 (2005).
[2]. Arnardottir, H., Orr, S.K., Dalli, J., et al. Human milk proresolving mediators stimulate resolution of acute inflammation. Mucosal. Immunol. 9(3), 757-766 (2016).
[3]. Winkler, J.W., Orr, S.K., Dalli, J., et al. Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance. Sci.Rep. 6, (2016).