Nedocromil suppresses the action or formation of multiple mediators, includinghistamine,leukotriene C₄(LTC₄), andprostaglandin D₂(PGD₂).

Nedocromil inhibits the release of histamine, LTC₄, and PGD₂from mast cells challenged with antigen (with IC₃₀values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC₃₀values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively)^[1].

Nedocromil-treated diabetic mice show significantly improved heart function compared with controls. The contractility and relaxation forces show similar improvements. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice. Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function^[2].

371.34

Solid

C₁₉H₁₇NO₇

69049-73-6

奈多罗米

Room temperature in continental US; may vary elsewhere.

DMSO : 16.67 mg/mL(44.89 mM;Need ultrasonic)

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