Agomelatin-d3 (S-20098-d3) is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist ofMT1andMT2receptors withK_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively^[1]. Agomelatine is a selective5-HT2C receptorantagonist withpK_is of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively^[2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

246.32

C₁₅H₁₄D₃NO₂

1079389-38-0

阿戈美拉汀 d3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.