CAS NO: | 52906-92-0 |
包装 | 价格(元) |
500 μg | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
生物活性 | Motilin (26-47), human, porcine is an endogenousmotilin receptorligand withKiandEC50of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line. | ||||||
IC50& Target | EC50: 0.3 nM (motilin receptor, Chinese hamster ovary cell)[1] | ||||||
体外研究 (In Vitro) | [Bpa1,Ile13]motilin is a full agonist at the motilin receptor that increases intracellular calcium in a concentration-dependent manner (EC50= 1.5 ± 0.4 nM)[1]. Motilin binds with high affinity (IC500.7± 0.2 nM) to receptors on smooth muscle cells. Motilin selectively activates G(q) and G(13), stimulates G alpha(q)-dependent phosphoinositide (PI) hydrolysis and 1,4,5-trisphosphate (IP(3))-dependent Ca2+release, and increases cytosolic free Ca2+. Motilin induces a biphasic, concentration-dependent contraction (EC50= 1.0 +/- 0.2 nM), consisting of an initial peak followed by a sustained contraction[2]. | ||||||
分子量 | 2699.07 | ||||||
性状 | Solid | ||||||
Formula | C120H188N34O35S | ||||||
CAS 号 | 52906-92-0 | ||||||
Sequence | Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln | ||||||
Sequence Shortening | FVPIFTYGELQRMQEKERNKGQ | ||||||
中文名称 | 胃动素 (人类,猪) | ||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||
储存方式 | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |