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Motilin(26-47),human,porcine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:52906-92-0
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议
10mg电议
50mg电议

产品名称
胃动素 (人类,猪)
产品介绍
Motilin (26-47), human, porcine 是一种内源性的motilin 受体激动剂,在中国仓鼠卵巢细胞中,Ki值和EC50值分别为 2.3 nM 和 0.3 nM。
生物活性

Motilin (26-47), human, porcine is an endogenousmotilin receptorligand withKiandEC50of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.

IC50& Target

EC50: 0.3 nM (motilin receptor, Chinese hamster ovary cell)[1]
Ki: 2.3 nM (motilin receptor, Chinese hamster ovary cell)[1]

体外研究
(In Vitro)

[Bpa1,Ile13]motilin is a full agonist at the motilin receptor that increases intracellular calcium in a concentration-dependent manner (EC50= 1.5 ± 0.4 nM)[1]. Motilin binds with high affinity (IC500.7± 0.2 nM) to receptors on smooth muscle cells. Motilin selectively activates G(q) and G(13), stimulates G alpha(q)-dependent phosphoinositide (PI) hydrolysis and 1,4,5-trisphosphate (IP(3))-dependent Ca2+release, and increases cytosolic free Ca2+. Motilin induces a biphasic, concentration-dependent contraction (EC50= 1.0 +/- 0.2 nM), consisting of an initial peak followed by a sustained contraction[2].

分子量

2699.07

性状

Solid

Formula

C120H188N34O35S

CAS 号

52906-92-0

Sequence

Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln

Sequence Shortening

FVPIFTYGELQRMQEKERNKGQ

中文名称

胃动素 (人类,猪)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)