CAS NO: | 290297-26-6 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Netupitant (CID-6451149) is a highly potent, selective and orally activeneurokinin-1 (NK1)receptor antagonist with aKiof 0.95 nM for hNK1in CHO cells. Netupitant has antiemetic affect[1][2][3]. | ||||||||||||||||
体外研究 (In Vitro) | Netupitant (CID-6451149) binds with high affinity the human NK1receptor (pKi=9.0) with more than 1000 fold selectivity over the NK2and NK3(pKi=5.8 for both sites)[2]. | ||||||||||||||||
体内研究 (In Vivo) | Netupitant (CID-6451149; 1-10 mg/kg; ip) dose-dependently inhibits SP-elicited the typical scratching, biting and licking response in mice. In gerbils, foot tapping behavior evoked by the intracerebroventricular injection of a NK1agonist is dose-dependently counteracted by Netupitant given intraperitoneally (ID501.5mg/kg) or orally (ID500.5mg/kg)[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 578.59 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C30H32F6N4O | ||||||||||||||||
CAS 号 | 290297-26-6 | ||||||||||||||||
中文名称 | 奈妥吡坦;萘妥吡坦 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 9.09 mg/mL(15.71 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |