[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA)，Neurokinin A 的类似物，是一种选择性且有效的NK2R激动剂。[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) 具有促运动活性。[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) 可用于研究 NK-2 受体在多种组织平滑肌收缩中的作用。
| 生物活性 | [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potentNK2Ragonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues[1][2][3]. |
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体内研究
(In Vivo) | [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (30-100 μg/kg，皮下注射) 增加了小型猪的膀胱和结肠直肠压力峰值[1]。
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (0.3 μg/kg 静脉注射或 100 μg/kg 鼻腔吸入) 也会增加膀胱和结肠直肠压力[1]。
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (10-100 μg/kg，静脉注射，每天四次，连续六天) 在有意识的狗中引起排尿和排便、呕吐和低血压[2].
| Animal Model: | Anesthetized minipigs[1] | | Dosage: | 30-100 μg/kg | | Administration: | Subcutaneous injection (s.c.) | | Result: | Showed significant, non-linear, dose-dependent increase in peak bladder and colorectal pressures, and was blocked byGR 159897(HY-107691)(1 mg/kg i.v., 15 min prior to LMN-NKA). |
| Animal Model: | Conscious dogs[2] | | Dosage: | 10-100 μg/kg | | Administration: | Intravenous injection (i.v.), four times daily for six consecutive days. | | Result: | Elicited NK2 receptor-mediated micturition defecation and NK1 receptor-mediated emesis and hypotension.
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
![[Lys5,MeLeu9,Nle10]Neurokinin A(4-10)图片](http://www.cnreagent.com/data/daily/2022/10/18/154314_681205_umcs_1046514.gif)
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