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Necrostatin-1 Inactive Control
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Necrostatin-1 Inactive Control图片
CAS NO:64419-92-7
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍

Necrostatin-1 Inactive Control (Nec-1i) is a demethylated variant of necrostatin-1, a RIP1 kinase inhibitor.

Cas No.64419-92-7
别名Nec-1i
化学名5-(1H-indol-3-ylmethyl)-2-thioxo-4-imidazolidinone
Canonical SMILESO=C(C(N1)CC2=CNC3=CC=CC=C32)NC1=S
分子式C12H11N3OS
分子量245.3
溶解度3mg/mL in ethanol, 14mg/mL in DMSO, 20mg/mL in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Necrostatin-1 Inactive Control (Nec-1i) is a demethylated variant of necrostatin-1, a RIP1 kinase inhibitor.[1] While both Nec-1 and Nec-1i inhibit the immune regulator indoleamine 2,3-dioxygenase, Nec1i is ~ 100-fold less effective than Nec-1 in inhibiting RIP1 kinase in vitro and 10-fold less potent than Nec-1 in a mouse necroptosis assay.[2] However, equally high doses of Nec-1 and Nec-1i are reported to inhibit TNF-induced systemic inflammatory response syndrome in vivo.[2] Nec-1i is often used as an inactive control in studies using Nec-1 to exclude nonspecific off-target effects.

Reference:
[1]. Degterev, A., Hitomi, J., Germscheid, M., et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chemical Biology 4(5), 313-321 (2008).
[2]. Takahashi, N., Duprez, L., Grootjans, S., et al. Necrostatin-1 analogues: Critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis. 3, e437 (2012).