CAS NO: | 380899-24-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | SB-649868 is a potent and selective orally activeorexin(OX)1andOX2receptor antagonist (pKi=9.4 and 9.5 at the OX1andOX2receptor, respectively). | ||||||||||||||||
IC50& Target | pKi: 9.4 (OX1), 9.5 (OX2)[1] | ||||||||||||||||
体外研究 (In Vitro) | SB-649868 is identified as one the most in vitro potent dual OX1and OX2receptor antagonist known at that time (pKi=9.4 and 9.5 at the OX1and OX2receptor, respectively)[1]. SB-649868 antagonizes orexin-A-induced inositol 1 phosphate (IP1) accumulation with the following pKBvalue (OX1=9.67; OX2=9.64). SB-649868 displaces the [3H]ACT-078573 receptor binding with the following pKi values: OX1=9.27; OX2=8.91. Increasing concentrations of SB-649868 (0.3 nM-30 nM) induces a rightward shift of the orexin-A CRCs with a depression of the agonist efficacy suggesting a clear non-surmountable behavior. The calculated apparent pKbvalues are 9.67±0.03 and 9.64±0.07 for OX1and OX2[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 477.55 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C26H24FN3O3S | ||||||||||||||||
CAS 号 | 380899-24-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(209.40 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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