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Barusiban
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Barusiban图片
CAS NO:285571-64-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
FE-200440
产品介绍
Barusiban (FE-200440) 是一种催产素受体 (OT-R) 拮抗剂 (Ki=0.8 nM),可抑制 OT 引起的收缩。Barusiban 可用于早产 (PTL)、体外受精 (IVF) 和不孕症的研究。
生物活性

Barusiban (FE-200440) is anoxytocin receptor(OT-R) antagonist (Ki=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research[1][2][3].

体外研究
(In Vitro)

Barusiban shows affinity for oxytocin receptor (Ki=0.8 nM) in COS cells expressed with oxytocin receptor[3].

体内研究
(In Vivo)

Barusiban (intravenous injection; 50 or 150 μg/kg; once) treatment shows inhibition on OT-induced contractions[2].

Animal Model:Pregnant cynomolgus monkeys injected with oxytocin (OT)[2]
Dosage:50 or 150 μg/kg
Administration:Intravenous injection; 50 or 150 μg/kg; once
Result:Reduced uterine contractions to baseline levels effectively.
Reduced intrauterine pressure (IUP) from 6-7.5 kmm Hgoh to approximately 1 kmm Hgoh.
Clinical Trial
分子量

830.05

Formula

C40H63N9O8S

CAS 号

285571-64-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.