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MRS2279 diammonium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MRS2279 diammonium图片
CAS NO:2387505-47-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
MRS2279 diammonium 是一种选择性、高亲和力的P2Y1受体拮抗剂,Ki为 2.5 nM,IC50为 51.6 nM。MRS2279 diammonium 竞争性抑制 ADP 促进的血小板聚集,pKb值为 8.05。
生物活性

MRS2279 diammonium is a selective and high affinityP2Y1receptor antagonist, with aKivalue of 2.5 nM and anIC50value of 51.6 nM. MRS2279 diammonium competitively inhibits ADP-promoted platelet aggregation with anpKbvalue of 8.05[1][2][3].

IC50& Target

P2Y1 Receptor

51.6 nM (IC50)

体外研究
(In Vitro)

MRS2279 diammonium antagonizes 2-MeSADP-stimulated inositol phosphate formation in turkey erythrocyte membranes with a pKbvalue of 7.75[2].
MRS2279 diammonium shows high affinity competitive antagonism to human P2Y1 receptor with a pKbvalue of 8.10 in 1321N1 human astrocytoma cells[2].
MRS2279 diammonium shows specific effect for the P2Y1 receptor, but shows no effect on activation of the human P2Y2, P2Y4, P2Y6, or P2Y11 receptors by their cognate agonists[2].
MRS2279 diammonium shows no ability to block the capacity of ADP to act through the Gi/adenylyl cyclase linked P2Y receptor of platelets to inhibit cyclic AMP accumulation[2].

体内研究
(In Vivo)

MRS2279 diammonium (2 μL, 1 nM; intracerebroventricular injection; 30 min prior to mechanical ventilation) reduces mouse brain injury induced by mechanical ventilation in high-pressure ventilation mice[3].

分子量

503.77

性状

Solid

Formula

C13H24ClN7O8P2

CAS 号

2387505-47-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)