CAS NO: | 2387505-47-5 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
生物活性 | MRS2279 diammonium is a selective and high affinityP2Y1receptor antagonist, with aKivalue of 2.5 nM and anIC50value of 51.6 nM. MRS2279 diammonium competitively inhibits ADP-promoted platelet aggregation with anpKbvalue of 8.05[1][2][3]. | |
IC50& Target |
| |
体外研究 (In Vitro) | MRS2279 diammonium antagonizes 2-MeSADP-stimulated inositol phosphate formation in turkey erythrocyte membranes with a pKbvalue of 7.75[2].MRS2279 diammonium shows high affinity competitive antagonism to human P2Y1 receptor with a pKbvalue of 8.10 in 1321N1 human astrocytoma cells[2].MRS2279 diammonium shows specific effect for the P2Y1 receptor, but shows no effect on activation of the human P2Y2, P2Y4, P2Y6, or P2Y11 receptors by their cognate agonists[2].MRS2279 diammonium shows no ability to block the capacity of ADP to act through the Gi/adenylyl cyclase linked P2Y receptor of platelets to inhibit cyclic AMP accumulation[2]. | |
体内研究 (In Vivo) | MRS2279 diammonium (2 μL, 1 nM; intracerebroventricular injection; 30 min prior to mechanical ventilation) reduces mouse brain injury induced by mechanical ventilation in high-pressure ventilation mice[3]. | |
分子量 | 503.77 | |
性状 | Solid | |
Formula | C13H24ClN7O8P2 | |
CAS 号 | 2387505-47-5 | |
运输条件 | Room temperature in continental US; may vary elsewhere. | |
储存方式 | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |