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Tetrahydropiperine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tetrahydropiperine图片
CAS NO:23434-88-0
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
四氢胡椒碱是胡椒碱的环己基类似物,是第一个来自长胡椒的天然芳基戊酰胺。 Tetrahydropiperine (compound 14) 抑制细胞色素 P450 (CYP) 异构体 CYP1A1/芳烃羟化酶 (AHH; IC50=23 μM)。
Cas No.23434-88-0
别名四氢胡椒碱
Canonical SMILESO=C(CCCCC1=CC(OCO2)=C2C=C1)N3CCCCC3
分子式C17H23NO3
分子量289.4
溶解度DMF: 10 mg/mL,DMSO: 10 mg/mL,DMSO:PBS (pH 7.2) (1:7): 0.1 mg/mL,Ethanol: 10 mg/mL
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tetrahydropiperine is a derivative of piperine and an arylpentanamide originally isolated from P. longum that has diverse biological activities. It is an agonist of transient receptor potential vanilloid type 1 (TRPV1; EC50 = 6.3 µM). It inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50 = 23 µM) and 7-methoxycoumarin O-demethylase (MOCD) activity (IC50 = 25 µM) in rat liver microsomes. Tetrahydropiperine increases skin pigmentation in a mouse model of vitiligo when 100 µl of a 175 mM solution is administered topically, an effect that can be enhanced by subsequent suberythemal ultraviolet radiation (UVR). Formulations containing tetrahydropiperine have been used to increase bioavailability of compounds applied to the skin.