您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Protease-Activated Receptor-1 antagonist 3
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Protease-Activated Receptor-1 antagonist 3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Protease-Activated Receptor-1 antagonist 3图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Protease-Activated Receptor-1 antagonist 3 是一种有效的 蛋白酶激活受体 1protease-activated receptor-1拮抗剂,IC50值为 7 nM。Protease-Activated Receptor-1 antagonist 3 显示与 hERG K+通道的结合亲和力,IC50值为 9 μM[1 ]
生物活性

Protease-Activated Receptor-1 antagonist 3 is a potentprotease-activated receptor-1antagonist with anIC50value of 7 nM. Protease-Activated Receptor-1 antagonist 3 shows binding affinity for hERG K+channel with anIC50value of 9 μM[1].

IC50& Target[1]

PAR1

7 nM (IC50)

体内研究
(In Vivo)

Protease-Activated Receptor-1 antagonist 3 (compound 23) (3 mg/kg; i.v.) shows 10% bioavailability in rats[1].

Animal Model:Rats[1]
Dosage:3 mg/kg
Administration:I.v.
Result:Exhibited relatively high unbound clearance values with CLuof 742 mL/min/kg, and Vdof 1.2 L/kg in rats.
分子量

498.62

Formula

C30H34N4O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.