包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | G12Si-5 formic is a covalent inhibitor of theG12Smutant ofK-Ras(Ki: 26 μM). G12Si-5 formic binds with the S-IIP domain and suppresses oncogenic signaling. G12Si-5 formic reduces phospho-ERK level in KRAS G12S mutated cells[1]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | G12Si-5 (10 μM, 2 h) formic leads to nearly complete loss of RasoGTP and concomitant inhibition of phospho-ERK in A549 cells[1]. Western Blot Analysis[1]
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分子量 | 620.07 | ||||||||
Formula | C32H31ClFN5O5 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |