CYN 154806 TFA

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CYN 154806 TFA

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

CYN 154806 TFA 是一种环状八肽，是一种强效的，选择性生长抑素sst2受体的拮抗剂，其对人重组 sst2、sst1、sst3、sst4 和 sst5 受体的pIC₅₀值分别为 8.58、5.41、6.07、5.76 和 6.48。

生物活性

CYN 154806 TFA, a cyclic octapeptide, is a potent and selectivesomatostatin sst2receptor antagonist, withpIC₅₀values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively^[1]^[2].

IC₅₀& Target

Somatostatin Receptor^[1]

体外研究
(In Vitro)

CYN 154806 TFA inhibits SRIF-induced increases in extracellular acidification (EAR) in CHO-K1 cells expressing human sst2 receptors (pKB 7.92). CYN 154806 TFA also blocks SRIF-induced increases [35S]-GTPγS binding in CHO-K1 cell membranes expressing human sst2 receptors as well as rat sst2(a) and rat sst2(b) receptors (pKB 7.81, 7.68 and 7.96, respectively)^[2].

体内研究
(In Vivo)

CYN 154806 TFA (0.1 mg/kg; i.p.; 20 min before the administration of carbachol (CCh) (30 μg/kg) in M4 KO mice) dose-dependently and significantly reverses the decreases acid response to CCh in M4 but not M3 KO mice^[3].

分子量

1311.36

性状

Solid

Formula

C₅₈H₆₉F₃N₁₂O₁₆S₂

Sequence

Ac-Phe(4-NO2)-Cys-Tyr-Trp-Lys-Thr-Cys-Tyr-NH2 (Disulfide bridge: Cys2-Cys7)

Sequence Shortening

Ac-F(4-NO2)CYWKTCY-NH2 (Disulfide bridge: Cys2-Cys7)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 25 mg/mL(19.06 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.7626 mL	3.8128 mL	7.6257 mL
5 mM	0.1525 mL	0.7626 mL	1.5251 mL
10 mM	0.0763 mL	0.3813 mL	0.7626 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。