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cis-Epoxysuccinic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
cis-Epoxysuccinic acid图片
CAS NO:16533-72-5
包装与价格:
包装价格(元)
100mg电议
500mg电议
1 g电议
5 g电议

产品介绍
cis-Epoxysuccinic acid 是succinate receptor (SUCNR1/GPR91)的激动剂。cis-Epoxysuccinic acid 抑制 cAMP 的水平,其EC50值为 2.7 μM。cis-Epoxysuccinic acid 可用于心血管系统的研究。
生物活性

cis-Epoxysuccinic acid is asuccinate receptor(SUCNR1/GPR91)agonist. cis-Epoxysuccinic acid inhibits cAMP levels with anEC50value of 2.7 μM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system[1].

体外研究
(In Vitro)

cis-Epoxysuccinic acid (1-100 μM; 10 min) affects cAMP levels of HEK293 cells[1].
cis-Epoxysuccinic acid (0.1 μM-100 mM; 1 h) agonists SUCNR1 pathways without affects succinate dehydrogenase[1].

Cell Viability Assay[1]

Cell Line:HEK293 cells
Concentration:1, 10 and 100 μM
Incubation Time:10 min
Result:Inhibited cAMP levels with an EC50value of 2.7 μM.

Cell Viability Assay[1]

Cell Line:HEK293 cells
Concentration:0.1 μM-100 mM
Incubation Time:1 hour
Result:Induced the Gq pathway, recruited arrestin 3 and elicited [Ca2+]imobilization with EC50values of 42, 74 and 191 μM, respectively.
体内研究
(In Vivo)

cis-Epoxysuccinic acid (1 mg/kg; i.v. once) has an effect on the blood pressure of rats[1].

Animal Model:Male Wistar rats[1]
Dosage:1 mg/kg
Administration:Intravenous injection; 1 mg/kg once
Result:Showed in vivo activity and increased blood pressure after injection.
分子量

132.07

性状

Solid

Formula

C4H4O5

CAS 号

16533-72-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : ≥ 250 mg/mL(1892.94 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM7.5717 mL37.8587 mL75.7174 mL
5 mM1.5143 mL7.5717 mL15.1435 mL
10 mM0.7572 mL3.7859 mL7.5717 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。