包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
生物活性 | Urotensin II, mouse is an endogenous ligand for the orphan G-protein-coupled receptorGPR14or SENR. Urotensin II, mouse is a potent vasoconstrictor. Urotensin II, mouse plays a physiological role in the central nervous system[1]. | ||||||||||||||||||||
IC50& Target | GPR14[1] | ||||||||||||||||||||
体外研究 (In Vitro) | This sequence of the C-terminus cyclic region of Urotensin II (U-II) is completely conserved in most species, including in the fish, frog, human, porcine, rat, and mouse, and it is thought to be essential for the agonistic activity of U-II. Urotensin II plays a physiological role in the central nervous system. Intracerebroventricular administration of Urotensin II induces anxiogenic-like behaviors in the elevated plus maze test and the hole-board test in mice in a dose-dependent manner, as do corticotropin releasing factor (CRF). The effective doses of Urotensin II are 10-100-fold higher than these of CRF in these tests[1]. | ||||||||||||||||||||
体内研究 (In Vivo) | Urotensin II is a somatostatin-like cyclic peptide which functions as an arterial vasocontrictor, vasodilator, and bronchoconstriction mediator[1].
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分子量 | 1633.86 | ||||||||||||||||||||
Formula | C76H100N18O19S2 | ||||||||||||||||||||
Sequence | {pGlu}-His-Gly-Ala-Ala-Pro-Glu-Cys-Phe-Trp-Lys-Tyr-Cys-Ile (Disulfide bridge: Cys8-Cys13) | ||||||||||||||||||||
Sequence Shortening | {pGlu}-HGAAPECFWKYCI (Disulfide bridge: Cys8-Cys13) | ||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. | ||||||||||||||||||||
Solvent & Solubility | In Vitro: H2O Peptide Solubility and Storage Guidelines: 1. Calculate the length of the peptide. 2. Calculate the overall charge of the entire peptide according to the following table:
3. Recommended solution:
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