GNE-2256 (molecule 19) 是一种具有口服活性的IRAK4(白介素 1 受体关联激酶 4) 抑制剂 (IRAK4Ki=1.4 nM; IL-6IC50=190 nM)。
生物活性 | GNE-2256 (molecule 19) is an orally activeIRAK4(Interleukin 1 receptor associated kinase 4) inhibitor (IRAK4Ki=1.4 nM;IL-6IC50=190 nM)[1]. |
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体内研究 (In Vivo) | GNE-2256 (3 mg/kg) shows inhibition of IL-6, TNFα, and IFNα secretion in R848-induced mouse PD model[1].
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运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |