您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Revexepride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Revexepride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Revexepride图片
CAS NO:219984-49-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Revexepride是一种高度选择性的5-HT4receptor激动剂,也是潜在的CYP3A4enzyme诱导剂,可用于治疗胃食管返流疾病。
Cas No.219984-49-3
Canonical SMILESO=C(C1=C(OC(C)(C)C2)C2=C(N)C(Cl)=C1)NC[C@H]3[C@H](O)CN(CCCOC)CC3
分子式C21H32ClN3O4
分子量425.95
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Revexepride is a highly selective 5-HT4 receptor agonist, and a potential inducer of CYP3A4 enzyme, used for the treatment of gastroesophageal reflux disease.

The human CYP isoenzymes are involved in the metabolism of revexepride, which is mainly metabolized in vitro in humans by CYP3A4 (99.9%) with a minor contribution of CYP2D6 (0.1%). Revexepride exhibits direct inhibition of human CYP3A4 in vitro with IC50 values of 16-49 μM[1].

[1]. David Pierce, et al. A phase 1 randomized study evaluating the effect of omeprazole on the pharmacokinetics of a novel 5-hydroxytryptamine receptor 4 agonist, revexepride (SSP-002358), in healthy adults. Drug Des Devel Ther. 2015; 9: 1257-1268.