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CCR2 antagonist 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CCR2 antagonist 1图片
CAS NO:1683534-96-4
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议

产品介绍
CCR2antagonist1是C-C趋化因子受体2型(CCR2)高亲和力、长时间作用的拮抗剂,其Ki值为2.4nM。
Cas No.1683534-96-4
Canonical SMILESO=C([C@]1(C(C)C)C[C@H](N[C@@H]2CCC3=C2C=CC(Br)=C3)CC1)N4CC5=C(C=CC(C(F)(F)F)=C5)CC4
分子式C28H32BrF3N2O
分子量549.47
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.

The combination of SAR and SKR in the hit-to-lead process results in the discovery of a new higheaffinity and longeresidenceetime CCR2 antagonist (CCR2 antagonist 1 (compound 15a), Ki=2.4 nM; RT=714 min)[1].

[1]. Vilums M, et al. When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists. Eur J Med Chem. 2015 Mar 26;93:121-34.