| CAS NO: | 1127452-94-1 |
| 包装: | 500μg |
| 市场价: | 4521元 |
| Cas No. | 1127452-94-1 |
| 别名 | 氨曲南-D6,SQ-26,776-d6 |
| Canonical SMILES | OS(N([C@@H](C)[C@@H]1NC(/C(C2=CSC(N)=N2)=N\OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(O)=O)=O)C1=O)(=O)=O |
| 分子式 | C13H11D6N5O8S2 |
| 分子量 | 441.5 |
| 溶解度 | DMSO: slightly soluble,Methanol: slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Aztreonam-d6 is intended for use as an internal standard for the quantification of aztreonam by GC- or LC-MS. Aztreonam is a synthetic β-lactam antibiotic of the monobactam class.1 It is active against clinical isolates of E. coli, S. marcescens, P. aeruginosa, Klebsiella species, Proteus species, and Enterobacter species (MICs = <0.1, 1.2, 5.2, 3.1, <0.1, and 19.3 μg/ml, respectively) but is inactive against S. pneumoniae, B. fragilis, and S. faecalis (MICs = >100 μg/ml for all). It interferes with peptidoglycan synthesis in the bacterial cell wall of the Gram-negative bacteria E. coli, P. vulgaris, E. cloacae, K. pneumoniae, and P. aeruginosa by inhibiting penicillin-binding protein 3 (PBP3; IC100 = 0.1 μg/ml for all). It increases survival in mice with systemic Gram-negative bacterial infections (ED50s = 0.1-24.7 mg/kg). Formulations containing aztreonam have been used in the treatment of P. aeruginosa infections in individuals with cystic fibrosis. |1. Sykes, R.B., Bonner, D.P., Bush, K., et al. Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria. Antimicrob. Agents Chemother. 21(1), 85-92 (1982). |
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