4-Hydroxychalcone

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4-Hydroxychalcone

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

20426-12-4

包装与价格：

包装	价格(元)
Free Sample (0.1-0.5mg)	电议
10mM (in 1mL DMSO)	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

4-Hydroxychalcone 是查尔酮代谢物，具有抗血管生成和消炎作用。 4-Hydroxychalcone 通过抑制生长因子途径抑制血管生成，无细胞毒性迹象。4-Hydroxychalcone 抑制 TNF-α 诱导的 NF-κB 途径活化并激活 BMP 信号传导，通过减轻小鼠的醛固酮过多症和肾脏损伤来降低抵抗性高血压 (RH)。

Cas No.	20426-12-4
别名	2-羟基查耳酮
Canonical SMILES	O=C(C1=CC=CC=C1)/C=C/C2=CC=C(O)C=C2
分子式	C₁₅H₁₂O₂
分子量	224.25
溶解度	DMSO: ≥ 250 mg/mL (1114.83 mM)
储存条件	4°C, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2]. [1]. Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691(1-3):125-33. [2]. Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.